Bicyclol solid preparation and preparation method thereof

一种双环醇固体制剂及其制备方法

Abstract

本发明公开了一种双环醇固体制剂及其制备方法。由于双环醇为难溶性药物,因此采用微粉化方式进行处理,减小粒径。将主药双环醇、填充剂和增溶剂进行联合共研微粉化,降低了微粉化难度,溶出效果好,生物利用度高,且操作简便、工艺稳定。
The invention discloses a bicyclol solid preparation and a preparation method of the bicyclol solid preparation. Because the bicyclol is a slightly soluble drug, the bicyclol is treated by adopting a micronization mode, and the particle size is reduced. The main drug bicyclol, a filling agent and a solubilizer are combined, ground and micronized, the micronization difficulty is reduced, the dissolution effect is good, the bioavailability is high, and the bicyclol solid preparation is simple and convenient in operation and stable in process.

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Patent Citations (2)

    Publication numberPublication dateAssigneeTitle
    CN-101390851-AMarch 25, 2009北京协和药厂双环醇含表面活性剂的药物组合物及其制剂
    CN-1608621-AApril 27, 2005中国医学科学院药物研究所Fine bicyclic alcohol powder and oral bicyclic alcohol release controlling prepn

NO-Patent Citations (1)

    Title
    储茂泉等: "丹参酮-预胶化淀粉共研磨混合物的研究", 《中国现代应用药学杂志》, vol. 18, no. 5, 31 October 2001 (2001-10-31), pages 359 - 362

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